Naproxen
Naproxen, there are various types and strengths of naproxen. Regular naproxen tablets contain 250 milligrams (mg), 375 mg, or 500 mg of naproxen.
Fast-absorbing naproxen sodium is available in 220 mg OTC capsules and tablets, and 275 mg and 550 mg tablets by prescription. Low-dose naproxen is available in tablet or capsule form.
Children and people who have difficulty swallowing tablets can use naproxen suspension. Naproxen suspension contains 125 mg of the drug per 5 milliliters (mL).
The following table lists the inactive ingredients in regular naproxen, naproxen sodium, and naproxen suspension. People who have allergies or intolerances to any inactive ingredients should avoid using naproxen.
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| Naproxen | Naproxen sodium | Naproxen suspension |
|---|---|---|
| • microcrystalline cellulose • croscarmellose sodium • magnesium stearate • iron oxide • povidone |
• microcrystalline cellulose • croscarmellose sodium • povidone • magnesium stearate • colloidal silicon dioxide • talc |
• methylparaben • fumaric acid • magnesium aluminum silicate • sodium chloride • sorbitol solution 70% • sucrose • flavor • FD&C Yellow No. 6 |
Naproxen is also available in enteric-coated tablets. These tablets release naproxen in the intestine rather than in the stomach. This formulation helps prevent gastrointestinal side effects that manufacturers have sometimes associated with naproxen.
Similarly to regular naproxen, enteric-coated tablets come in tablets of 375 mg and 500 mg.
Naproxen is available as tablets, liquid capsules, and liquid.
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The dose of naproxen that a person requires depends on why they are using the medication. A general rule is to use the lowest effective dose for the shortest possible duration. This dosing helps prevent side effects from occurring.
Doctors advise people to take naproxen and other NSAIDs with food to prevent nausea or other gastrointestinal side effects.
Mild to moderate pain
For fever and mild to moderate pain, adults can take one 220 mgTrusted Source tablet of naproxen every 12 hours. Children under 12 years old should not take naproxen unless their doctor recommends it.
Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis
People can manage the symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis with a dose of 220 mg to 550 mg of naproxen every 12 hours.
Naproxen does not cure these conditions but offers relief from pain and inflammation.
Acute gout attacks
People with acute gout attacks may take 825 mg for one dose, followed by 275 mg every 8 hours.
Learn more about gout treatments.
Juvenile rheumatoid arthritis
Doctors may prescribe naproxen to manage the pain and inflammation caused by juvenile rheumatoid arthritis.
People can administer the liquid suspension of naproxen to children 2 years old and older. The recommended dose is 10 mg per kilogram (kg), or mg/kg divided into two doses 12 hours apart.
Headaches
Using naproxen to relieve pain from headaches and migraine is controversial.
People can try taking 550 mg of naproxen sodium every 12 hours and may increase it to 825 mg if needed. The daily dose should not exceed 1,375 mg.
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Naproxen sodium is degraded more slowly than regular naproxen and other NSAIDs. This means that naproxen sodium should remain active for longer than other anti-inflammatory drugs.
However, after 2 hours, headache pain relief is lower with naproxen sodium than with other NSAIDs.
Although naproxen can be used to reduce the pain of headaches and migraine headaches, other NSAIDs may provide better relief.
Learn about natural headache remedies.
Maximum recommended daily dose
People should only use OTC naproxen for a short-term period. It is best to stop taking naproxen and contact a doctor if pain remains for more than 10 days, or more than 3 days for fever.
For children between 2 and 12 years old, the maximum daily doseTrusted Source by weight is 20 mg/kg. They should not be taking more than 1,000 mg in 24 hours.
When OTC medications, children 12 years and older should not take more than 660 mg in 24 hours.
Studies have not shown any benefit in using daily doses higher than 1,000 mg for adults, but some sources suggest a maximum of 1,650 mg per day for up to 6 months for arthritis.
The frequency and severity of side effects that naproxen causes depend on several factors.
Considerations include the dose and duration of treatment, other medical diagnoses a person may have, and individual risk factors.
The following sections discuss the common and serious side effects of naproxen.
Possible side effects
Possible side effects of naproxen include:
- heartburn
- constipation
- nausea
- gas
- headache
- dizziness
- itchy skin
- changes in urination
- excessive thirst
- hearing problems or ringing in the ears
- tingling sensation in the arms or legs
- symptoms of the common cold
Serious side effects
Examples of serious side effects of naproxen include:
- heart attack
- stroke
- blood clots
- jaundice
- symptoms of an allergic reaction
Although people can buy low dose naproxen without a prescription, it is not safe for everyone.
People with serious heart conditions, such as heart disease, cerebrovascular disease, and congestive heart failure, may experience severe side effects from taking naproxen.
People with high blood pressure should only take naproxen cautiously.
Naproxen can cause sodium retention in the kidneys, which can result in increased blood pressure. A person with high blood pressure should consult their doctor before taking naproxen.
Gastrointestinal side effects of taking naproxen can be severe. Bleeding in the stomach, the formation of ulcers, and stomach or intestinal blockages can occur when taking naproxen. Older adults and those with a history of ulcers or gastrointestinal bleeding may be more vulnerable to more serious gastrointestinal side effects.
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Anaphylaxis: Symptoms and what to do
Anaphylaxis is a severe allergic reaction that can be life threatening. The symptoms develop suddenly and include:
- hives
- swelling of the face or mouth
- wheezing
- fast, shallow breathing
- a fast heart rate
- clammy skin
- anxiety or confusion
- dizziness
- vomiting
- blue or white lips
- fainting or loss of consciousness
If someone has these symptoms:
- Check whether they are carrying an epinephrine pen. If they are, follow the instructions on the side of the pen to use it.
- Dial 911 or the number of the nearest emergency department.
- Lay the person down from a standing position. If they have vomited, turn them onto their side.
- Stay with them until the emergency services arrive.
Some people may need more than one epinephrine injection. If the symptoms do not improve in 5–15 minutes, or they come back, use a second pen if the person has one.
Naproxen may interact with several prescription and nonprescription drugs. Drinking alcohol and taking naproxen may increase the risk of gastrointestinal side effects.
